Management of immune checkpoint inhibitor‐related adverse events: A review of case reports
Identifieur interne : 000116 ( an2020/Analysis ); précédent : 000115; suivant : 000117Management of immune checkpoint inhibitor‐related adverse events: A review of case reports
Auteurs : Xiaoyan Si ; Peng Song ; Jun Ni ; Mingyi Di ; Chunxia He ; Li Zhang ; Xiaowei Liu ; Yue Li ; Hanping Wang ; Xiaoxiao Guo ; Jiaxin Zhou ; Lian Duan ; Xu Yang ; Mengzhao Wang ; Li ZhangSource :
- Thoracic Cancer [ 1759-7706 ] ; 2020.
Abstract
Immune checkpoint inhibitors represent a major breakthrough in cancer therapy. Immune‐related adverse events (irAEs) may occur during treatment due to their unique mechanism of action. Management of irAEs is based on clinical experience because it is not easy to conduct prospective trials to evaluate the best treatment strategy. Using a combination of search terms in the PubMed and Embase databases, we reviewed all cases in the English language citing toxicities associated with either pembrolizumab, nivolumab, ipilimumab, atezolizumab, tremelimumab, durvalumab, avelumab or any combination of these agents published before 20 May 2019. A total of 128 reports with 239 cases were included in the study. Here, we summarize the spectrum of toxicities, safety in special patients, rechallenging after irAEs and agents used for treatment of irAEs in those reports.
Url:
DOI: 10.1111/1759-7714.13315
PubMed: 31970923
PubMed Central: 7049490
Affiliations:
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PMC:7049490Le document en format XML
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sortKey="Di, Mingyi" sort="Di, Mingyi" uniqKey="Di M" first="Mingyi" last="Di">Mingyi Di</name><affiliation><nlm:aff id="tca13315-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="He, Chunxia" sort="He, Chunxia" uniqKey="He C" first="Chunxia" last="He">Chunxia He</name><affiliation><nlm:aff id="tca13315-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><affiliation><nlm:aff id="tca13315-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Liu, Xiaowei" sort="Liu, Xiaowei" uniqKey="Liu X" first="Xiaowei" last="Liu">Xiaowei Liu</name><affiliation><nlm:aff id="tca13315-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Li, Yue" sort="Li, Yue" uniqKey="Li Y" first="Yue" last="Li">Yue Li</name><affiliation><nlm:aff id="tca13315-aff-0005"></nlm:aff></affiliation></author><author><name sortKey="Wang, Hanping" sort="Wang, Hanping" uniqKey="Wang H" first="Hanping" last="Wang">Hanping Wang</name><affiliation><nlm:aff id="tca13315-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Guo, Xiaoxiao" sort="Guo, Xiaoxiao" uniqKey="Guo X" first="Xiaoxiao" last="Guo">Xiaoxiao Guo</name><affiliation><nlm:aff id="tca13315-aff-0006"></nlm:aff></affiliation></author><author><name sortKey="Zhou, Jiaxin" sort="Zhou, Jiaxin" uniqKey="Zhou J" first="Jiaxin" last="Zhou">Jiaxin Zhou</name><affiliation><nlm:aff id="tca13315-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Duan, Lian" sort="Duan, Lian" uniqKey="Duan L" first="Lian" last="Duan">Lian Duan</name><affiliation><nlm:aff id="tca13315-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Yang, Xu" sort="Yang, Xu" uniqKey="Yang X" first="Xu" last="Yang">Xu Yang</name><affiliation><nlm:aff id="tca13315-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Wang, Mengzhao" sort="Wang, Mengzhao" uniqKey="Wang M" first="Mengzhao" last="Wang">Mengzhao Wang</name><affiliation><nlm:aff id="tca13315-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><affiliation><nlm:aff id="tca13315-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Thoracic Cancer</title><idno type="ISSN">1759-7706</idno><idno type="eISSN">1759-7714</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Immune checkpoint inhibitors represent a major breakthrough in cancer therapy. Immune‐related adverse events (irAEs) may occur during treatment due to their unique mechanism of action. Management of irAEs is based on clinical experience because it is not easy to conduct prospective trials to evaluate the best treatment strategy. Using a combination of search terms in the PubMed and Embase databases, we reviewed all cases in the English language citing toxicities associated with either pembrolizumab, nivolumab, ipilimumab, atezolizumab, tremelimumab, durvalumab, avelumab or any combination of these agents published before 20 May 2019. A total of 128 reports with 239 cases were included in the study. Here, we summarize the spectrum of toxicities, safety in special patients, rechallenging after irAEs and agents used for treatment of irAEs in those reports.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Di, Mingyi" sort="Di, Mingyi" uniqKey="Di M" first="Mingyi" last="Di">Mingyi Di</name><name sortKey="Duan, Lian" sort="Duan, Lian" uniqKey="Duan L" first="Lian" last="Duan">Lian Duan</name><name sortKey="Guo, Xiaoxiao" sort="Guo, Xiaoxiao" uniqKey="Guo X" first="Xiaoxiao" last="Guo">Xiaoxiao Guo</name><name sortKey="He, Chunxia" sort="He, Chunxia" uniqKey="He C" first="Chunxia" last="He">Chunxia He</name><name sortKey="Li, Yue" sort="Li, Yue" uniqKey="Li Y" first="Yue" last="Li">Yue Li</name><name sortKey="Liu, Xiaowei" sort="Liu, Xiaowei" uniqKey="Liu X" first="Xiaowei" last="Liu">Xiaowei Liu</name><name sortKey="Ni, Jun" sort="Ni, Jun" uniqKey="Ni J" first="Jun" last="Ni">Jun Ni</name><name sortKey="Si, Xiaoyan" sort="Si, Xiaoyan" uniqKey="Si X" first="Xiaoyan" last="Si">Xiaoyan Si</name><name sortKey="Song, Peng" sort="Song, Peng" uniqKey="Song P" first="Peng" last="Song">Peng Song</name><name sortKey="Wang, Hanping" sort="Wang, Hanping" uniqKey="Wang H" first="Hanping" last="Wang">Hanping Wang</name><name sortKey="Wang, Mengzhao" sort="Wang, Mengzhao" uniqKey="Wang M" first="Mengzhao" last="Wang">Mengzhao Wang</name><name sortKey="Yang, Xu" sort="Yang, Xu" uniqKey="Yang X" first="Xu" last="Yang">Xu Yang</name><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><name sortKey="Zhou, Jiaxin" sort="Zhou, Jiaxin" uniqKey="Zhou J" first="Jiaxin" last="Zhou">Jiaxin Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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